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The Collaborative Pediatric Critical Care Research Network Critical Pertussis Study: collaborative research in

Jeri S Burr1, Tammara L Jenkins, Rick Harrison

  • 1University of Utah (JSB), Salt Lake City, UT, USA. jeri.burr@hsc.utah.edu

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|November 9, 2010
PubMed

Insights

Despite high childhood vaccination rates, pertussis (whooping cough) remains a serious threat to US children, causing critical illness and death. Research is urgently needed to improve management strategies for this severe disease.

Area of Science:

  • Pediatric Critical Care Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • Pertussis (whooping cough) continues to cause significant morbidity and mortality in US children, particularly infants, despite widespread childhood vaccination.
  • Bordetella pertussis is a recognized community-acquired pathogen leading to critical illness and death in pediatric intensive care units (PICUs).
  • Knowledge gaps exist regarding the long-term medical and developmental sequelae in survivors of critical pertussis and optimal treatment strategies.

Purpose of the Study:

  • To present an updated overview of critical pertussis for the pediatric critical care community.
  • To describe the ongoing Collaborative Pediatric Critical Care Research Network (CPCCRN) Critical Pertussis Study.

Main Methods:

  • A prospective cohort study is being conducted.
  • Data collection involves multiple sites, including the CPCCRN network and academic medical centers with PICUs.

Main Results:

  • Pertussis remains a significant cause of critical illness and death in US children, even with high vaccination coverage.
  • The study aims to address the unknown incidence of sequelae and unclear management strategies for critical pertussis.

Conclusions:

  • Urgent research is required to establish an evidence base for optimizing the management of critical pertussis.
  • Critical pertussis is a severe, disabling, and often fatal illness affecting children in the US and globally.
Abstract

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