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Updated: Jun 6, 2026
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Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
Published on: November 16, 2018
Multiple calcifying hyperplastic dental follicles: comparison with hyperplastic dental follicles
Young-Ah Cho1, Hye-Jung Yoon, Sam-Pyo Hong
1Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
Summary
Multiple calcifying hyperplastic dental follicles (MCHDF) is a rare disorder affecting males, characterized by impacted teeth and calcified follicles. This study distinguishes MCHDF from hyperplastic dental follicles (HDF), noting earlier and more widespread calcification in MCHDF.
Area of Science:
- Oral pathology
- Dental radiology
- Histopathology
Background:
- Multiple calcifying hyperplastic dental follicles (MCHDF) is a rare condition involving multiple impacted teeth and enlarged dental follicles with calcifications.
- Limited characterization of MCHDF hinders prompt differential diagnosis by clinicians.
- This study aims to characterize MCHDF by analyzing clinical and histopathological features.
Purpose of the Study:
- To compare the clinical and histopathological features of MCHDF with hyperplastic dental follicles (HDF) associated with singly impacted teeth.
- To establish MCHDF as a distinct pathological entity.
Main Methods:
- Clinical and histopathological examination of five MCHDF cases.
- Comparison of these cases with data from 50 singly impacted teeth exhibiting HDFs.
Main Results:
- All five MCHDF patients were male, with consistent impaction of second molars.
- Observed dental anomalies included supernumerary or congenitally missing teeth.
- Microscopic analysis revealed calcifications consistent with MCHDF and HDF, with MCHDF showing earlier and more generalized calcification.
Conclusions:
- MCHDF is identified as a distinct pathological entity with a male predilection and earlier calcification compared to HDF.
- Further research is required to elucidate the etiology, treatment options, and eruption mechanisms of MCHDF.
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