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Updated: Jun 6, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Sleep-related deglutition in patients with OSAHS under CPAP therapy
Kiminori Sato1, Hirohito Umeno, Shun-ichi Chitose
1Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan. kimisato@oct-net.ne.jp
Conclusion:
Continuous positive airway pressure (CPAP) therapy improved not only apnea-hypopnea during sleep and sleep structure but also sleep-related deglutition, especially respiratory phase patterns associated with deglutition.
Objectives:
Sleep-related deglutition and related respiratory phase patterns in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) under CPAP therapy were investigated.
Methods:
Deglutition during sleep was examined in 10 patients who had severe OSAHS under CPAP therapy via time-matched recordings of polysomnography and surface electromyography.
Results:
The mean number of swallows per hour during the total sleep time was 1.6 ± 1.3. The mean period of the longest absence of deglutition was 66.4 ± 19.6 min. Deglutition was related to the sleep stage. The mean number of swallows per hour was 6.8 ± 8.4 during stage 1 sleep, 1.1 ± 0.8 during stage 2 sleep, 0.1 ± 0.4 during stage 3 sleep, and 0 during stage 4 sleep. The deeper the sleep stage, the lower the mean deglutition frequency. The mean number of swallows per hour was 0.8 ± 0.5 during REM sleep. Most deglutition occurred in association with spontaneous electroencephalographic arousal. Swallows followed by inspiration were markedly reduced. Under CPAP therapy, sleep-related deglutition and its respiratory phase pattern had normalized.
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