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Updated: Jun 6, 2026
10:16
In Vitro Enzyme Measurement to Test Pharmacological Chaperone Responsiveness in Fabry and Pompe Disease
Published on: December 20, 2017
BRENDA, the enzyme information system in 2011.
Maurice Scheer1, Andreas Grote, Antje Chang
1Department for Bioinformatics and Biochemistry, Technische Universität Braunschweig, Langer Kamp 19 B, 38106 Braunschweig, Germany.
Nucleic Acids Research
|November 11, 2010
Summary
The BRENDA enzyme database enhances enzyme data accessibility with over 100,000 references and improved tools for function, structure, and pathway analysis. This update facilitates enzyme research and metabolic modeling.
Area of Science:
- Biochemistry
- Bioinformatics
- Enzymology
Background:
- The BRENDA enzyme information system is a primary resource for enzyme functional and property data.
- Data is primarily manually extracted from scientific literature.
Purpose of the Study:
- To update and enhance the BRENDA database with new data and improved functionalities.
- To facilitate enzyme research, data processing, and metabolic modeling.
Main Methods:
- Manual extraction of data from primary literature.
- Implementation of new query, analysis, and data management tools.
- Integration of pathway maps and disease text mining.
Main Results:
- Increased manually annotated references by 30% to over 100,000.
- Increased ligand structures by 45% to almost 100,000.
- Introduced new viewing options including 3D structure visualization and pathway maps.
Conclusions:
- BRENDA provides enhanced data access and analysis tools for enzymes.
- New features support metabolic modeling and disease research.
- The database continues to be a vital resource for the scientific community.
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