Related Experiment Video
Updated: Jun 6, 2026
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Retinoblastoma in NWFP, Pakistan
Muhammad Arif1, Zafar Iqbal, Zia-ul-Islam
1Department of Ophthalmology, Khyber Teaching Hospital, Peshawar, Pakistan. arifmdn@yahoo.com
Background:
Retinoblastoma is a malignant intraocular tumour of childhood, if not detected early, it results in loss of eye as well as life. The Objective was to study the pattern of presentation of Retinoblastoma in order to detect the disease at an earlier stage. It was conducted at Supra Regional Referral Centre for Retinoblastoma, Department of Ophthalmology, Khyber Teaching Hospital, Peshawar, Pakistan from 1st July 1999 to 30th September 2002.
Methods:
Seventy patients were registered and admitted for diagnostic evaluation. After initial interview a proforma was filled about history of disease. Examination under anaesthesia included indirect ophthalmoscopy with indentation. B-scan of the eye and CT scan of the Orbit was done when required.
Results:
Forty (57.14%) patients presented with Leukocoria; other presentation included hyphaema, strabismus, proptosis, 56.48% patients presented in stage VB (Rees Elsworth classification).
Conclusion:
Early detection through better understanding of presenting features of the disease and application of diagnostic skills can reduce the advanced stage of Retinoblastoma.
Related Concept Videos
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...