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Updated: Jun 6, 2026
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Obesity related kidney disease
Anna V Mathew1, Shinichi Okada, Kumar Sharma
1Center for Renal Translational Medicine, University of California-San Diego/Veterans Affairs San Diego Healthcare System, CA 92093-0711, USA.
Current Diabetes Reviews
|November 12, 2010
Summary
Obesity contributes to chronic kidney disease, causing albuminuria and glomerulosclerosis. Interventions like weight loss and renin-angiotensin system blockade may improve kidney health.
Area of Science:
- Nephrology
- Endocrinology
- Pathology
Background:
- Obesity is a significant risk factor for developing new-onset kidney disease.
- It also exacerbates existing chronic kidney disease (CKD).
- Obesity-related kidney disease features albuminuria, glomerulomegaly, and focal glomerulosclerosis.
Purpose of the Study:
- To review the pathological changes in the kidneys associated with obesity.
- To discuss the mechanisms, including hemodynamic and hormonal factors, involved in obesity-related kidney disease.
- To explore potential therapeutic strategies for mitigating kidney damage in obese individuals.
Main Methods:
- Review of existing literature on obesity and kidney disease.
- Analysis of pathophysiological mechanisms linking obesity to renal pathology.
- Synthesis of data on therapeutic interventions.
Main Results:
- Altered renal hemodynamics (hyperfiltration) and an upregulated renin-angiotensin system are traditionally implicated.
- Adipokines (e.g., adiponectin, leptin) and inflammatory markers from adipose tissue directly impact glomerular cells.
- These factors contribute to the characteristic pathological changes observed in obesity-related kidney disease.
Conclusions:
- Weight loss is a key strategy to manage obesity-related kidney disease.
- Blocking the renin-angiotensin system may offer renoprotection.
- Restoring adipokine balance could be a therapeutic target to ameliorate disease progression.
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