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Related Experiment Videos

Malignant cystosarcoma phylloides. Treatment and prognosis.

W Browder, J T McQuitty, J C McDonald

    American Journal of Surgery
    |August 1, 1978
    PubMed
    Summary

    Malignant cystosarcoma phyllodes rarely metastasizes to lymph nodes, making axillary dissection unnecessary. Wide resection is recommended due to common local recurrence, with lesion size being a key factor in patient mortality.

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    Area of Science:

    • Oncology
    • Surgical Pathology

    Background:

    • Malignant cystosarcoma phyllodes is a rare breast tumor.
    • Understanding its metastatic potential and treatment implications is crucial.

    Purpose of the Study:

    • To review cases of malignant cystosarcoma phyllodes.
    • To evaluate metastatic patterns and treatment outcomes.

    Main Methods:

    • Retrospective review of 26 malignant cystosarcoma phyllodes cases.
    • Analysis of clinical data, including metastasis, recurrence, and mortality.

    Main Results:

    • No axillary lymph node metastases were observed in any case.
    • Local recurrence was frequent, supporting wide local excision.
    • Tumor size was a significant predictor of mortality.
    • Low mitotic activity and minimal stromal atypia correlated with non-fatal outcomes.
    • Associated neoplasia, especially in the contralateral breast, was common.

    Conclusions:

    • Malignant cystosarcoma phyllodes has a low propensity for lymphatic metastasis, often obviating the need for axillary dissection.
    • Wide resection is essential for managing local recurrence.
    • Prognosis is influenced by tumor size and specific histological features.

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