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Updated: Jun 6, 2026

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure
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Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Published on: February 12, 2018

Time-resolved optical imaging of a solid tissue-equivalent phantom.

J C Hebden, D J Hall, M Firbank

    Applied Optics
    |November 12, 2010
    PubMed
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    Researchers developed a novel phantom mimicking breast tissue for near-infrared imaging. Time-resolved imaging shows potential for detecting low-contrast breast tumors, advancing medical diagnostics.

    Area of Science:

    • Biomedical Optics
    • Medical Imaging
    • Photon Transport Physics

    Background:

    • Accurate phantoms are crucial for developing and validating novel medical imaging techniques.
    • Human breast tissue optical properties present challenges for near-infrared (NIR) imaging.
    • Time-resolved imaging (TRI) offers potential for enhanced contrast and resolution in turbid media.

    Purpose of the Study:

    • To develop a solid plastic phantom with optical properties similar to human breast tissue at NIR wavelengths.
    • To evaluate the efficacy of a time-resolved imaging technique for detecting embedded low-contrast targets within the phantom.
    • To assess the feasibility of subcentimeter resolution imaging for potential breast tumor detection.

    Main Methods:

    • Fabrication of a 54-mm-thick solid plastic phantom containing four embedded cylinders with varying scattering and absorption properties.

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    Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy
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    Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
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    Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

    Published on: July 29, 2013

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    Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure
    10:22

    Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

    Published on: February 12, 2018

    Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy
    09:25

    Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy

    Published on: August 22, 2018

    Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
    06:33

    Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

    Published on: July 29, 2013

  • Application of a time-resolved imaging technique using transmitted light to capture photon flight times.
  • Comparison of images obtained with shortest photon flight times versus continuous light transillumination.
  • Utilizing an analytic model of photon transport to extrapolate temporal distributions and overcome photon detection limitations.

    • Main Results:

    • The developed phantom accurately replicates human breast tissue optical properties in the NIR spectrum.
    • Images from shortest photon flight times in TRI demonstrated superior visibility of embedded cylinders compared to continuous wave imaging.
    • Image quality degraded for flight times below approximately 700 picoseconds due to insufficient photon detection.
    • Extrapolation using an analytic photon transport model showed promise in mitigating image degradation.

    Conclusions:

    • The developed breast tissue optical phantom is a valuable tool for evaluating imaging systems.
    • Time-resolved imaging, despite challenges with photon detection at short flight times, shows significant potential for improved breast cancer detection.
    • Subcentimeter resolution imaging of low-contrast breast tumors is scientifically achievable with advanced imaging and modeling techniques.