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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

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Gateways to clinical trials.

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Gateways to clinical trials.

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Gateways to clinical trials.

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[Proceedings of the XVIII TASPE Seminar, Granada, Spain, 4-5 February 2010].

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Updated: Jun 6, 2026

In Silico Clinical Trials for Cardiovascular Disease
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In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Gateways to clinical trials.

A Tomillero1, M A Moral

  • 1Thomson Reuters, Barcelona, Spain. scientific.prousjournals@thomsonreuters.com

Methods and Findings in Experimental and Clinical Pharmacology
|November 12, 2010
PubMed
Summary
This summary is machine-generated.

This study reviews a comprehensive list of novel pharmaceutical compounds, including small molecules, biologics, and vaccines, for various therapeutic indications. The findings highlight advancements in drug development across multiple disease areas.

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Area of Science:

  • Pharmacology and Drug Development
  • Medicinal Chemistry
  • Biotechnology

Context:

  • The pharmaceutical landscape is rapidly evolving with the introduction of diverse therapeutic modalities.
  • This abstract compiles a broad spectrum of investigational drugs, encompassing small molecules, biologics, and vaccines.
  • The listed compounds target a wide array of diseases, reflecting the breadth of current research.

Purpose:

  • To provide an overview of emerging pharmaceutical agents across different therapeutic classes.
  • To catalog novel compounds including small molecules, monoclonal antibodies, and vaccines.
  • To identify key drug candidates in development for various medical conditions.

Summary:

  • A comprehensive list of pharmaceutical agents is presented, including Aclidinium bromide, Alemtuzumab, Amlodipine besylate/atorvastatin calcium, Bevacizumab, Bortezomib, Dapagliflozin, Dasatinib, Degarelix acetate, Enfuvirtide, Entecavir, Everolimus, Exenatide, Gefitinib, HPV-6/11/16/18 vaccine, Imatinib mesylate, Insulin detemir, Insulin glargine, Ivabradine hydrochloride, Lacosamide, Lenalidomide, Liraglutide, Methoxy polyethylene glycol-epoetin-β, Mirabegron, Olaparib, Olmesartan medoxomil, Panitumumab, Peginterferon alfa-2a, Pemetrexed disodium, Raltegravir potassium, Regadenoson, Roflumilast, Rosuvastatin calcium, Safinamide mesilate, Selumetinib, Sipuleucel-T, Sorafenib, Sunitinib malate, Tadalafil, Telaprevir, Testosterone transdermal gel, Tiotropium bromide, Tocilizumab, Tremelimumab, and Vorinostat.
  • The compilation spans small molecules, biologics (e.g., monoclonal antibodies, recombinant proteins), and vaccines.
  • These agents are under investigation for a multitude of indications, including oncology, metabolic disorders, cardiovascular diseases, and infectious diseases.

Impact:

  • Provides a valuable resource for researchers and clinicians tracking drug development pipelines.
  • Facilitates understanding of the breadth of therapeutic strategies being explored.
  • Informs future research directions and potential therapeutic interventions.