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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

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Related Experiment Videos

Pyoderma gangrenosum: an Indian perspective.

R M Bhat1, B Nandakishore, F F Sequeira

  • 1Department of Dermatology, Fr Muller Medical College, Mangalore, India. rameshderma@yahoo.com

Clinical and Experimental Dermatology
|November 13, 2010
PubMed
Summary
This summary is machine-generated.

Pyoderma gangrenosum (PG) is a rare neutrophilic skin disease. This study highlights its clinical features, common ulcerative type, and frequent association with systemic diseases in Indian patients.

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Area of Science:

  • Dermatology
  • Internal Medicine

Background:

  • Pyoderma gangrenosum (PG) is an uncommon, idiopathic, neutrophilic skin disease.
  • It is sometimes associated with systemic diseases.
  • This is the first reported case series of PG from India.

Purpose of the Study:

  • To investigate the clinical characteristics of PG.
  • To identify associated systemic diseases.
  • To evaluate treatment modalities for PG.

Main Methods:

  • A prospective study was conducted.
  • 18 cases of PG diagnosed at an institution in Mangalore were evaluated.
  • Clinical data, systemic associations, and treatment outcomes were analyzed.

Main Results:

  • Ulcerative PG was the predominant variant (94.44%).
  • Systemic diseases were present in over half of the patients (55.55%).
  • A positive pathergy test (38.88%) was significantly associated with systemic disease.

Conclusions:

  • PG, though rare in India, presents with common pediatric cases and a high prevalence of ulcerative forms.
  • Over half of the patients had associated systemic diseases, underscoring the need for comprehensive evaluation.
  • A positive pathergy test in patients with systemic disease warrants further investigation.