Multiple periorbital fibrous histiocytomas: a light and electron microscopic study

Area of Science:

• Dermatopathology
• Surgical Pathology
• Oncology

Background:

• Fibrous histiocytomas, also known as dermatofibromas, are common benign skin neoplasms.
• Periorbital involvement is uncommon, and multiple recurrent lesions are rare.
• This report focuses on a unique presentation of periorbital fibrous histiocytomas.

Observation:

• A 62-year-old woman presented with recurrent, bilateral, and multiple lesions around the eyes.
• Serum lipid levels were within normal limits, ruling out systemic lipid disorders.
• Histological examination revealed a mix of lipid-laden histiocytes and fibroblasts in a storiform pattern.

Findings:

• The tumor exhibited characteristic features of a fibrous histiocytoma.
• No cytologic atypia or evidence of malignancy was identified.
• Ultrastructural analysis confirmed the presence of lipid-laden histiocytes and fibroblasts with collagen production.

Implications:

• This case highlights the importance of considering fibrous histiocytomas in the differential diagnosis of periorbital tumors.
• Understanding the histogenesis and differential diagnosis is crucial for accurate patient management.
• Further research may elucidate specific factors contributing to periorbital recurrence.