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Inhibition of plasma hyaluronan-binding protein autoactivation by laccaic acid
Chikako Sekido1, Naoko Nishimura, Masayuki Takai
1Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Fuchu, Japan.
Abstract:
Plasma hyaluronan-binding protein (PHBP) is a serine protease implicated in proteolysis under inflammatory conditions. We identified laccaic acid, a widely used food coloring from scale insects, as a potent inhibitor of the protease in terms of both autoactivation of the PHBP proenzyme (IC(50) = 0.35-0.55 µg/ml) and the catalytic activity of the active enzyme (IC(50) = 1.1 µg/ml).
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