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Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria
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Zinc proteomes, phylogenetics and evolution.

Leonardo Decaria1, Ivano Bertini, Robert J P Williams

  • 1Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, Sesto Fiorentino, Italy.

Metallomics : Integrated Biometal Science
|November 13, 2010
PubMed
Summary
This summary is machine-generated.

This study explores the link between environmental chemical changes and organism evolution, focusing on inorganic ions. A bioinformatic analysis of zinc proteomes reveals correlations between protein evolution and environmental shifts.

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Area of Science:

  • Biochemistry
  • Evolutionary Biology
  • Bioinorganic Chemistry

Background:

  • Evolutionary studies traditionally focus on comparative, fossil, and molecular sequence data.
  • The influence of environmental chemical changes on evolution, particularly inorganic chemistry of organisms, requires further detailed investigation.
  • Understanding the early stages of evolutionary history remains a challenge.

Purpose of the Study:

  • To investigate the role of environmental chemical changes in organism evolution.
  • To characterize zinc proteomes using a bioinformatic approach.
  • To correlate changes in zinc-binding proteins with environmental shifts throughout evolution.

Main Methods:

  • Bioinformatic analysis of 821 fully sequenced organism DNA from NCBI.
  • Application of a published method for deducing zinc proteomes.
  • Comparative analysis of zinc-finger-containing proteins and zinc hydrolytic enzymes across organisms of varying complexity.

Main Results:

  • Successfully characterized zinc proteomes across diverse organisms.
  • Identified a correlation between the evolution of zinc-binding proteins and enzymes and environmental changes.
  • Demonstrated the utility of a bioinformatic approach in studying evolutionary chemistry.

Conclusions:

  • Environmental chemical changes are a significant driver of organism evolution.
  • Zinc proteomes and their associated proteins have co-evolved with environmental conditions.
  • This study provides a new perspective on evolutionary mechanisms by integrating inorganic chemistry and bioinformatics.