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Updated: May 2, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
Role of the B-cell receptor in chronic lymphocytic leukemia: where do we stand?
Franco Fais1, Silvia Bruno, Fabio Ghiotto
1Section of Human Anatomy, Department of Experimental Medicine, University of Genoa. franco.fais@unige.it
Abstract:
The past 15 years have witnessed an enormous effort in studying B-cell Chronic Lymphocytic Leukemia. A great number of researches brought significant novel information and a better understanding of the natural history of this disease. This mini review will focus on the studies related to the Immunoglobulin variable (IgV) genes rearrangements that compose the B-cell receptor (BcR) of the leukemic clones. These studies have defined a role for the antigen(s) in the paths that lead to leukemic clone generation/expansion and underscore the informative value represented by BcR analyses.
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