Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CD11c<sup>+</sup> T-Bet<sup>+</sup> B Cell Expansion Reveals a Distinct Pathogenic Signature in Autoimmune Liver Diseases.

Liver international : official journal of the International Association for the Study of the Liver·2026

Same author

Ileal Bile Acid Transporter Inhibitors for Symptomatic Cholestasis due to Vanishing Bile Duct Syndrome in Adults.

ACG case reports journal·2026

Same author

Spatial proteomics and cell-cell cross-talk analysis reveal PD-L1 and IL-6 interaction in human primary sclerosing cholangitis.

JHEP reports : innovation in hepatology·2026

Same author

Integrating Advanced Endoscopic Techniques and Confocal Microscopy for Early Detection of Extrahepatic Cholangiocarcinoma.

Cancers·2026

Same author

Bile Acid Sequestrants in Primary Sclerosing Cholangitis and the Risk of Acute Cholangitis: Cause for Concern?

Clinical and translational gastroenterology·2026

Same author

Management of Liver Cirrhosis in Percutaneous and Surgical Cardiac Interventions.

Journal of the American Heart Association·2026

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Multipotent stem cells in the biliary tree.

Vincenzo Cardinale¹, Yunfang Wang, Guido Carpino

¹Division of Gastroenterology, Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.

Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia

|November 16, 2010

Summary

The biliary tree contains stem cells that can regenerate liver, bile duct, and pancreas. These stem/progenitor cells persist into adulthood and offer potential for regenerative medicine applications.

More Related Videos

Generation of Organoids from Mouse Extrahepatic Bile Ducts

Generation of Organoids from Mouse Extrahepatic Bile Ducts

Published on: April 23, 2019

Isolation of Neonatal Extrahepatic Cholangiocytes

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

Related Experiment Videos

Last Updated: Jun 6, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Generation of Organoids from Mouse Extrahepatic Bile Ducts

Generation of Organoids from Mouse Extrahepatic Bile Ducts

Published on: April 23, 2019

Isolation of Neonatal Extrahepatic Cholangiocytes

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

Area of Science:

Developmental biology
Stem cell research
Regenerative medicine

Background:

The biliary tree system comprises intrahepatic and extrahepatic bile ducts.
Biliary tree and liver development share a common origin with the ventral pancreas.
A common progenitor for liver, biliary duct system, and ventral pancreas arises during foregut development.

Purpose of the Study:

To investigate the presence and potential of stem/progenitor cells within the adult biliary tree.
To explore the role of these cells in liver, bile duct, and pancreas regeneration.

Main Methods:

Review of existing studies on biliary tree development and stem cell compartments.
Analysis of stem cell niches within peribiliary glands and gallbladder.

Main Results:

The biliary tree harbors stem cell compartments for the liver, pancreas, and bile duct system.
These stem/progenitor cells persist into adulthood.
Peribiliary glands contain stem cells, potentially giving rise to progenitors in the gallbladder.

Conclusions:

The biliary tree represents a novel source of stem/progenitor cells.
These cells hold significant promise as tools for regenerative medicine in liver, bile duct, and pancreas therapies.