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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

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Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
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Paclitaxel-loaded nanoparticles by temperature-induced phase transition

Kinam Park1

  • 1Purdue University, Department of Biomedical Engineering and Pharmaceutics, West Lafayette, IN, USA. kpark@purdue.edu

Journal of Controlled Release : Official Journal of the Controlled Release Society
|November 16, 2010
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No abstract available in PubMed .

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