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Measurement of Particle Size Distribution in Turbid Solutions by Dynamic Light Scattering Microscopy
Published on: January 9, 2017
Photometric imaging in particle size measurement and surface visualization.
1Pharmaceutical Sciences Laboratory, Department of Biosciences, Åbo Akademi University, BioCity, Artillerigatan 6, 20520 Turku, Finland. niklas.sandler@abo.fi
International Journal of Pharmaceutics
|November 16, 2010
Summary
Photometric particle sizing offers an alternative to traditional methods, particularly for challenging moist or cohesive samples. This technique, focusing on photometric stereo imaging, enables 3D reconstruction and surface analysis.
Area of Science:
- Materials Science
- Chemical Engineering
- Analytical Chemistry
Background:
- Traditional particle size measurement methods often require particle dispersion, which is problematic for moist or cohesive samples.
- Photometric techniques offer an alternative approach for characterizing particles without dispersion.
Purpose of the Study:
- To provide insight into photometric particle sizing approaches.
- To highlight the advantages of photometric methods for difficult-to-disperse samples.
- To demonstrate the application of photometric stereo imaging for particle characterization.
Main Methods:
- Utilizing photometric stereo imaging for three-dimensional reconstruction of objects.
- Employing multiple light sources for illumination.
- Applying photometric techniques for at-line and on-line measurements.
Main Results:
- Demonstrated successful at-line measurement of granules.
- Showcased on-line measurement during granulation and dry milling processes.
- Briefly discussed surface visualization and roughness measurements.
Conclusions:
- Photometric particle sizing, especially using stereo imaging, is advantageous for moist or cohesive samples where dispersion is difficult.
- The technique allows for 3D reconstruction and surface analysis, expanding particle characterization capabilities.
- Photometric methods are applicable in various industrial settings, including granulation and milling.
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