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Updated: Jun 6, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
[Diabetes and chronic kidney disease: lessons from renal epidemiology]
Emmanuel Villar1, Philippe Zaoui
1Service de néphrologie, dialyse et transplantation rénale, centre hospitalier Lyon Sud, hospices civils de Lyon, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France. emmanuel.villar@chu-lyon.fr
Abstract:
In industrialized countries, renal epidemiology is faced with the growing epidemic of diabetes as cause of renal involvement or as an associated condition. In France, recent studies estimate that 400,000+ diabetics have a glomerular filtration rate lower than 60 mL/min/1.73 m², and that 7000+ are prevalent in dialysis. The vast majority has type 2 diabetes. In type 1 diabetes, renal prognosis improved over the last decade due to available aggressive glycemic control and treatment with renin-angiotensin system inhibitors. Diabetes has a negative impact on survival in end-stage renal disease, particularly for type 1 diabetes patients and for women with diabetes. In type 2 diabetes, improvement in early access to renal transplant could lead to improvement in outcomes, whereas they are usually contra-indicated for transplant because rapid decline in cardiovascular status on dialysis. All these epidemiological data help us to implement preventing measures and further researches in order to improve diabetes patient prognosis.
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