Related Experiment Video
Updated: Jun 6, 2026

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics
Published on: May 30, 2025
Existence and stability of steady states of a reaction convection diffusion equation modeling microtubule formation
Shantia Yarahmadian1, Blake Barker, Kevin Zumbrun
1Mississippi State University, Mississippi State, MS 39762, USA. syarahmadian@math.msstate.edu
Abstract:
We generalize the Dogterom-Leibler model for microtubule dynamics (Dogterom and Leibler in Phys Rev Lett 70(9):1347-1350, 1993) to the case where the rates of elongation as well as the lifetimes of the elongating shortening phases are a function of GTP-tubulin concentration. We analyze also the effect of nucleation rate in the form of a damping term which leads to new steady-states. For this model, we study existence and stability of steady states satisfying the boundary conditions at x=0. Our stability analysis introduces numerical and analytical Evans function computations as a new mathematical tool in the study of microtubule dynamics.
Related Concept Videos
Microtubule Instability
Microtubule Instability
Destabilization of Microtubules
Microtubule Formation
Assembly of Complex Microtubule Structures
Microtubules
Microtubules have two structurally similar globular protein subunits: α and β tubulins. In the cytosol, the α and β tubulins form a heterodimer. These αβ-heterodimers...

