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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Cardiovascular disease in chronic kidney disease: data from the Kidney Early Evaluation Program (KEEP)

Peter A McCullough1, Susan Steigerwalt, Kirit Tolia

  • 1Department of Medicine, Sections of Cardiology, Nephrology, and Endocrinology, St. John Providence Health System, Providence Park Hospital, Novi, MI, USA. peteramccullough@gmail.com

Current Diabetes Reports
|November 16, 2010
PubMed

Insights

Patients with chronic kidney disease (CKD) face higher risks of cardiovascular disease (CVD) and mortality. Targeted interventions are crucial for improving CKD patient risk factor control and reducing CVD events.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Diabetes mellitus (DM) and hypertension (HTN) are primary drivers of cardiovascular disease (CVD) and chronic kidney disease (CKD).
  • CKD is defined by estimated glomerular filtration rate <60 mL/min/1.73 m² or urine albumin:creatinine ratio ≥30 mg/g.
  • CKD is a significant risk factor for CVD, myocardial infarction, stroke, and mortality.

Purpose of the Study:

  • To analyze the prevalence of CKD and CVD in the Kidney Early Evaluation Program (KEEP).
  • To investigate the association between CKD, CVD, and mortality.
  • To evaluate CVD risk factor control in patients with CKD.

Main Methods:

  • Analysis of data from the nationwide KEEP cohort.
  • Definition of CKD based on established eGFR and albuminuria criteria.
  • Assessment of self-reported CVD, myocardial infarction, and stroke prevalence.

Main Results:

  • CKD prevalence was 25.7% and self-reported CVD was 22.1% in the KEEP cohort.
  • CKD was linked to younger ages at myocardial infarction and stroke.
  • Patients with CKD and CVD had shorter survival times.
  • Despite some improvements, the majority of CKD patients had uncontrolled blood pressure, glucose, or lipids.

Conclusions:

  • Patients with CKD exhibit elevated risks for CVD and mortality.
  • CKD patients are prime candidates for targeted interventions to improve risk factor management.
  • Community and practice-based interventions can potentially reduce cardiovascular events in CKD populations.

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