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Updated: Jun 6, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
A model of Varicella-Zoster reactivation
Jonathan E Forde1, Bailey Meeker
1Department of Mathematics and Computer Science, Hobart and William Smith Colleges, Geneva, NY 14456, United States. forde@hws.edu
Abstract:
Mathematical models have been used to study the dynamic interaction of many infectious diseases with the host's immune system. In this paper, we study Varicella Zoster Virus, which is responsible for chicken pox (varicella), and after a long period of latency, herpes zoster (shingles). After developing the model and demonstrating that is exhibits the type of periodic behavior necessary for long term latency and reactivation, we examine the implications of the model for vaccine booster programs aimed at preventing herpes zoster.
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