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Golimumab and certolizumab: the two new anti-tumor necrosis factor kids on the block

Mohit Mittal1, Siba P Raychaudhuri

  • 1Department of Medicine, Division of Rheumatology, VA Medical Center Sacramento and UC Davis School of Medicine, Allergy and Clinical Immunology, 105 35 Hospital Way, Mather, CA 95655, USA.

Indian Journal of Dermatology, Venereology and Leprology
|November 17, 2010
PubMed

Anti-tumor necrosis factor (anti-TNF) agents have revolutionized treatment of psoriasis and many other inflammatory diseases of autoimmune origin. They have considerable advantages over the existing immunomodulators. Anti-TNF agents are designed to target a very specific component of the immune-mediated inflammatory cascades. Thus, they have lower risks of systemic side-effects. In a brief period of 10 years, a growing number of biological therapies are entering the clinical arena while many more biologicals remain on the horizon. With time, the long-term side-effects and efficacies of these individual agents will become clearer and help to determine which ones are the most suitable for long-term care. Golimumab (a human monoclonal anti-TNF-α antibody) and Certolizumab (a PEGylated Fab fragment of humanized monoclonal TNF-α antibody) are the two latest additions to the anti-TNF regimen. Here, we are providing a brief description about these two drugs and their uses.

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