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Related Concept Videos

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

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Related Experiment Video

Updated: Jun 6, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
08:05

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

Administration of local anesthetic agents to decrease pain associated with peripheral vascular access.

Steven Anderson1, Jean Cockrell, Pat Beller

  • 1Emergency Department, Rex Healthcare, Raleigh, North Carolina 27607, USA. steven.anderson@rexhealth.com

Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society
|November 17, 2010
PubMed
Summary
This summary is machine-generated.

Local anesthetic injections before IV insertion may increase initial pain. Pain levels were similar across all groups after the IV was placed, suggesting intradermal anesthetics are not beneficial for patient comfort during IV placement.

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Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
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Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

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Last Updated: Jun 6, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
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Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Area of Science:

  • Pain management
  • Emergency medicine
  • Anesthesiology

Background:

  • Intravenous (IV) cannulation is a common procedure in emergency departments.
  • Patient comfort during IV insertion is a significant concern.
  • Local anesthetic agents are often considered to reduce pain during IV placement.

Purpose of the Study:

  • To compare the efficacy of various local anesthetic agents in reducing pain during IV device insertion.
  • To determine the most comfortable method for patients undergoing IV cannulation.

Main Methods:

  • A randomized, double-blind, placebo-controlled, pretest-posttest experimental design was employed.
  • Eighty-four emergency department patients were allocated to five groups: anesthetic spray, placebo spray, anesthetic intradermal injection, placebo intradermal injection, and a control group.
  • Pain was assessed using a visual analog scale before and after anesthetic application, and after IV insertion.

Main Results:

  • The anesthetic intradermal injection group reported significantly higher pain levels one minute post-application compared to other groups.
  • Pain ratings three minutes after IV insertion were comparable across all five treatment groups.
  • The study found no significant benefit of using intradermal anesthetic agents for pain reduction during IV insertion.

Conclusions:

  • Current evidence does not support the routine use of intradermal anesthetic agents prior to IV catheter insertion for enhanced patient comfort.
  • Intradermal anesthetic administration may transiently increase pain perception without providing long-term benefits for IV placement.