Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy.

Nature cancer·2025
Same author

Myofibroblastic CAFs arising from bone-resident osteoblast precursors retain an osteolineage signature and support breast cancer progression via Osterix-mediated signaling.

bioRxiv : the preprint server for biology·2025
Same author

SLC7A8 is essential for metabolic fitness and function of Th2 cells.

The Journal of experimental medicine·2025
Same author

Membrane IL-18 identifies a human macrophage subset with distinct proteomic and functional traits.

Oncoimmunology·2025
Same author

Dual threat: VSIG4⁺ macrophages use IL-11 and VSIG4 to silence T cells.

Developmental cell·2025
Same author

Fate mapping of peripherally-derived macrophages after traumatic brain injury in mice reveals a long-lasting population with a distinct transcriptomic signature.

Nature communications·2025
Same journal

Editorial Expression of Concern: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.

Nature immunology·2026
Same journal

Inflammatory immune modulators of AML lung infiltration and respiratory failure.

Nature immunology·2026
Same journal

The neuroimmune system and cognition.

Nature immunology·2026
Same journal

Critical connections.

Nature immunology·2026
Same journal

Innate immune signaling and functions in astrocytes.

Nature immunology·2026
Same journal

Epigenetic mechanisms of inflammatory memory in the central nervous system.

Nature immunology·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

Skin function for human CD1a-reactive T cells.

Marco Colonna1

  • 1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA. mcolonna@wustl.edu

Nature Immunology
|November 17, 2010
PubMed
Summary
This summary is machine-generated.

Human CD4+ T cells producing interleukin 22 are crucial for skin health. These cells identify CD1a-lipid complexes on Langerhans cells, revealing a new aspect of skin immunity.

More Related Videos

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue
06:27

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue

Published on: July 30, 2018

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

Related Experiment Videos

Last Updated: Jun 6, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue
06:27

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue

Published on: July 30, 2018

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Interleukin 22 (IL-22) producing CD4+ T cells play a vital role in maintaining skin homeostasis, barrier function, and wound healing.
  • Langerhans cells are key antigen-presenting cells in the epidermis, crucial for initiating immune responses.
  • The specific antigens recognized by CD4+ T cells on Langerhans cells in the context of skin immunity were not fully elucidated.

Discussion:

  • This study reveals a novel interaction pathway in skin immunity involving CD4+ T cells and Langerhans cells.
  • The recognition of CD1a-lipid complexes by T cells highlights a non-classical antigen presentation mechanism relevant to skin defense.
  • This finding deepens our understanding of the cellular crosstalk essential for skin integrity and immune surveillance.

Key Insights:

  • Human CD4+ T cells that produce IL-22 are essential for skin defense and repair.
  • These T cells specifically recognize CD1a-lipid complexes presented by Langerhans cells.
  • This interaction represents a critical link between innate and adaptive immunity in the skin.

Outlook:

  • Further research into CD1a-lipid antigen presentation could lead to new therapeutic strategies for skin diseases.
  • Understanding this T cell-Langerhans cell axis may offer insights into treating inflammatory skin conditions and promoting skin regeneration.
  • Investigating the precise nature of the lipids involved could uncover novel targets for immunomodulation in dermatology.