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A concise synthesis of the molecular framework of pleuromutilin
Junjia Liu1, Stephen D Lotesta, Erik J Sorensen
1Frick Chemical Laboratory, Department of Chemistry, Princeton University, Princeton, NJ 08540, USA.
Chemical Communications (Cambridge, England)
|November 17, 2010
Abstract:
Two syntheses of the tricyclic carbon skeleton of pleuromutilin are reported. Diastereoselective 1,4-conjugate additions were used to elaborate bicyclic precursors at an early stage of each route, while ring-forming olefin metatheses were executed to complete the pleuromutilin carbon framework. The congeners prepared are appropriately functionalized to enable access to diverse pleuromutilin analogues.
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