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Updated: Jun 6, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Design, synthesis and 3D-QSAR study of cytotoxic flavonoid derivatives
Lili Ou1, Shuang Han, Wenbo Ding
1Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Zijingang Campus, Hangzhou, Zhejiang 310058, People's Republic of China.
Abstract:
Three series of flavonoid derivatives were designed and synthesized. All synthesized compounds were evaluated for cytotoxic activities against five human cancer cell lines, including K562, PC-3, MCF-7, A549, and HO8910. Among the compounds tested, compound 9 d exhibited the most potent cytotoxic activity with IC(50) values of 2.76-6.98 μM. Further comparative molecular field analysis was performed to conduct a 3D quantitative structure-activity relationship study. The generated 3D-QSAR model could be used for further rational design of novel flavonoid analogs as highly potent cytotoxic agents.
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