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A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
Published on: January 7, 2018
Evidence-based pathology: umbilical cord coiling.
1SA Pathology, Women's and Children's Hospital, North Adelaide, South Australia, Australia. yee.khong@adelaide.edu
Pathology
|November 18, 2010
Summary
The umbilical cord coiling index may not be evidence-based due to inconsistent calculations and definitions. This impacts the reliability of pathology test results for umbilical cord abnormalities.
Area of Science:
- Pathology
- Obstetrics
- Perinatology
Background:
- Pathology test results require reproducible and clinically relevant criteria for evidence-based practice.
- The umbilical cord coiling index is a commonly used metric in obstetrics.
Purpose of the Study:
- To deconstruct the umbilical cord coiling index and assess its evidence base.
- To identify factors that may cause the umbilical cord coiling index to deviate from evidence-based standards.
Main Methods:
- Systematic review of publications on umbilical cord coiling.
- Analysis of methods for calculating the umbilical coiling index.
- Evaluation of definitions for abnormal coiling and construction of reference ranges.
Main Results:
- Inconsistencies exist in the calculation of the umbilical coiling index.
- Definitions of abnormal umbilical cord coiling lack standardization.
- Reference ranges for hypocoiling and hypercoiling do not account for measurement errors or gestational age.
Conclusions:
- The generation of the umbilical cord coiling index may be compromised by measurement errors and inconsistent definitions.
- Critical analysis of the evidence base for numerical pathology test results, like the umbilical coiling index, is necessary.
- Ensuring reproducibility and minimizing errors are crucial for evidence-based pathology testing.
