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PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways

Claudia Krag1, Emily Kim Malmberg, Anna Elisabetta Salcini

  • 1Biotech Research and Innovation Centre, BRIC, University of Copenhagen, Ole Maaløes Vej 5, DK2200 Copenhagen, Denmark.

Journal of Cell Science
|November 18, 2010
PubMed
Summary

Phosphoinositide 3-kinase C2α (PI3KC2α) regulates dynamin-independent endocytosis. This pathway is crucial for cellular uptake of molecules like diphtheria toxin (DT) and CD59, involving early endosome antigen 1 (EEA1) recruitment.

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