Related Experiment Video
Updated: Jun 6, 2026
09:22
In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
Identification of dihydropyridines that reduce cellular tau levels
Christopher G Evans1, Umesh K Jinwal, Leah N Makley
1Department of Pathology and the Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Ann Arbor, MI 48109, USA.
Chemical Communications (Cambridge, England)
|November 18, 2010
Abstract:
A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships.
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