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GIP and bariatric surgery.
Raghavendra S Rao1, Subhash Kini
1Division of Metabolic, Endocrine and Minimally Invasive Surgery, Department of Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA. Raghavendra.Rao@Mountsinai.org
Obesity Surgery
|November 18, 2010
Summary
Bariatric surgery effectively treats obesity and type 2 diabetes. The role of glucose-dependent insulinotropic polypeptide (GIP) in these outcomes after surgery is debated, with human and animal studies showing conflicting results.
Area of Science:
- Endocrinology
- Metabolic Surgery
- Diabetes Research
Background:
- Bariatric surgery is a leading treatment for obesity and type 2 diabetes mellitus (T2DM).
- Glucose-dependent insulinotropic polypeptide (GIP), an incretin hormone, is linked to obesity and T2DM pathogenesis.
- The specific function of GIP in the context of bariatric surgery outcomes remains unclear and controversial.
Purpose of the Study:
- To review the physiological role of GIP.
- To examine GIP's involvement in weight loss following bariatric surgery.
- To investigate GIP's contribution to T2DM resolution after bariatric procedures.
Main Methods:
- Literature review of original research articles.
- Inclusion of both human and animal studies.
- Searched PubMed for relevant publications.
Main Results:
- Human studies generally indicate a reduction in GIP levels after malabsorptive bariatric surgery.
- Findings from animal experimental models regarding GIP's role are inconclusive.
- The precise impact of GIP on surgical weight loss and diabetes remission is still debated.
Conclusions:
- The role of GIP in the success of bariatric surgery for weight loss and T2DM resolution requires further investigation.
- Discrepancies between human and animal study results highlight the complexity of GIP's function.
- Clarifying GIP's role could inform future therapeutic strategies for obesity and T2DM.
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