Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of Posterior Quadratus Lumborum Block vs Surgical Wound Infiltration in Patients Undergoing Bariatric Sleeve Gastrectomy Surgery.

Obesity surgery·2025
Same author

Responsiveness and Reliability of a Sipping Device to Measure Motivation in Normal-Weight Individuals and Bariatric Surgery Patients.

Nutrients·2024
Same author

Progressive Non-familial Adult onset Cerebellar Degeneration: An Unusual Occurrence with Hashimoto's Thyroiditis.

Psychopharmacology bulletin·2018
Same author

The Long-Term Effects of the Adjustable Gastric Band on Esophageal Motility in Patients Who Present for Band Removal.

Obesity surgery·2017
Same author

Laparoscopic Sleeve Gastrectomy and Gastric Bypass for The Aging Population.

Obesity surgery·2016
Same author

Role of fatty-acid synthesis in dendritic cell generation and function.

Journal of immunology (Baltimore, Md. : 1950)·2013
Same journal

Correction: Predictive Effect of Preoperative Bone Marrow Fat Fraction on Postoperative Bone Mineral Density After Bariatric Surgery: a Prospective Cohort Study.

Obesity surgery·2026
Same journal

Paired Editorials: Patient Satisfaction and Experience with Same-day Discharge After Laparoscopic Roux-en-Y Gastric Bypass: a Mixed-methods Study.

Obesity surgery·2026
Same journal

Better Prepared Than Surprised: A Call to Routinize Preparedness - Essentials of Pre- and Post-Operative Counselling on Psychological Challenges After Metabolic and Bariatric Surgery.

Obesity surgery·2026
Same journal

Associations Between Opioid Timing and Postoperative Desaturation Burden Following Metabolic Bariatric Surgery.

Obesity surgery·2026
Same journal

Outcomes of Metabolic and Bariatric Surgery Among Adolescents and Young Adults in Southern Louisiana.

Obesity surgery·2026
Same journal

Cohort-Based Reference Percentiles for six BODY-Q Health-Related Quality of Life Scales after Metabolic and Bariatric Surgery.

Obesity surgery·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

GIP and bariatric surgery.

Raghavendra S Rao1, Subhash Kini

  • 1Division of Metabolic, Endocrine and Minimally Invasive Surgery, Department of Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA. Raghavendra.Rao@Mountsinai.org

Obesity Surgery
|November 18, 2010
PubMed
Summary
This summary is machine-generated.

Bariatric surgery effectively treats obesity and type 2 diabetes. The role of glucose-dependent insulinotropic polypeptide (GIP) in these outcomes after surgery is debated, with human and animal studies showing conflicting results.

More Related Videos

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
08:50

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

Published on: October 18, 2024

A Murine Model of Vertical Sleeve Gastrectomy
06:47

A Murine Model of Vertical Sleeve Gastrectomy

Published on: December 18, 2017

Related Experiment Videos

Last Updated: Jun 6, 2026

Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
08:50

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

Published on: October 18, 2024

A Murine Model of Vertical Sleeve Gastrectomy
06:47

A Murine Model of Vertical Sleeve Gastrectomy

Published on: December 18, 2017

Area of Science:

  • Endocrinology
  • Metabolic Surgery
  • Diabetes Research

Background:

  • Bariatric surgery is a leading treatment for obesity and type 2 diabetes mellitus (T2DM).
  • Glucose-dependent insulinotropic polypeptide (GIP), an incretin hormone, is linked to obesity and T2DM pathogenesis.
  • The specific function of GIP in the context of bariatric surgery outcomes remains unclear and controversial.

Purpose of the Study:

  • To review the physiological role of GIP.
  • To examine GIP's involvement in weight loss following bariatric surgery.
  • To investigate GIP's contribution to T2DM resolution after bariatric procedures.

Main Methods:

  • Literature review of original research articles.
  • Inclusion of both human and animal studies.
  • Searched PubMed for relevant publications.

Main Results:

  • Human studies generally indicate a reduction in GIP levels after malabsorptive bariatric surgery.
  • Findings from animal experimental models regarding GIP's role are inconclusive.
  • The precise impact of GIP on surgical weight loss and diabetes remission is still debated.

Conclusions:

  • The role of GIP in the success of bariatric surgery for weight loss and T2DM resolution requires further investigation.
  • Discrepancies between human and animal study results highlight the complexity of GIP's function.
  • Clarifying GIP's role could inform future therapeutic strategies for obesity and T2DM.