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Related Experiment Video

Updated: Jun 6, 2026

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells

Published on: March 5, 2019

Adipose-derived stem cells for skin regeneration.

Hiroshi Mizuno¹, Masaki Nambu

¹Department of Plastic and Reconstructive Surgery, School of Medicine, Juntendo University, Tokyo, Japan.

Methods in Molecular Biology (Clifton, N.J.)

|November 18, 2010

Summary

Adipose-derived stem cells (ASCs) show promise for treating difficult skin ulcers. This study developed a hybrid artificial dermis using ASCs and collagen sponges, demonstrating improved wound healing in an experimental model.

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Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

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Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

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Published on: October 31, 2012

Area of Science:

Regenerative Medicine
Wound Healing
Biomaterials

Background:

Intractable skin ulcers from diabetes, ischemia, and collagen diseases lack effective treatments.
Cell-based therapy offers a potential solution for these challenging wounds.

Purpose of the Study:

To establish an experimental model for treating intractable ulcers using stem cells.
To evaluate the efficacy of adipose-derived stem cells (ASCs) in a hybrid artificial dermis for wound healing.

Main Methods:

Isolation of adipose-derived stem cells (ASCs).
Preparation of a hybrid artificial dermis using a type I collagen sponge seeded with ASCs.
Induction of intractable ulcers using Mitomycin C in an experimental model.
Histological evaluation of wound healing, including capillary density and granulation tissue thickness.

Main Results:

The hybrid artificial dermis with ASCs was applied to Mitomycin C-induced ulcers.
Histological analysis after 1 and 2 weeks showed increased capillary density.
Enhanced granulation tissue thickness was observed in the treated ulcers.

Conclusions:

Adipose-derived stem cells (ASCs) demonstrate a positive effect on wound healing.
The hybrid artificial dermis incorporating ASCs is a promising tool for cell-based therapy of intractable ulcers.