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Updated: Jun 6, 2026
05:47
Phosphoproteomic Strategy for Profiling Osmotic Stress Signaling in Arabidopsis
Published on: June 25, 2020
Phosphoproteome resource for systems biology research
Bernd Bodenmiller1, Ruedi Aebersold
1Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. bodenmiller@imsb.biol.ethz.ch
Methods in Molecular Biology (Clifton, N.J.)
|November 18, 2010
Summary
PhosphoPep 2.0 offers interactive access to mass spectrometry (MS)-derived phosphorylation data for systems biology research. This database integrates crucial signaling information from yeast, worm, fly, and human.
Area of Science:
- Biochemistry
- Molecular Biology
- Systems Biology
Background:
- Post-translational modifications, particularly phosphorylation, are critical regulators of cellular signaling pathways.
- Understanding these modifications is essential for deciphering complex biological systems.
Purpose of the Study:
- To introduce PhosphoPep version 2.0, a curated database for systems biology research.
- To provide interactive tools for interrogating mass spectrometry (MS)-derived phosphorylation data.
Main Methods:
- Compilation of phosphorylation data from multiple model organisms.
- Development of an interactive database interface for data exploration.
Main Results:
- The PhosphoPep database currently hosts phosphorylation data from four key organisms: yeast (Saccharomyces cerevisiae), worm (Caenorhabditis elegans), fly (Drosophila melanogaster), and human (Homo sapiens).
- The database enables interactive querying and analysis of MS-derived phosphoproteomic data.
Conclusions:
- PhosphoPep 2.0 serves as a valuable resource for researchers investigating cellular signaling networks.
- The integrated, cross-species phosphorylation data facilitates comparative and systems-level analyses.
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