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Updated: Jun 6, 2026

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal
Published on: May 30, 2012
Myc transcription factors: key regulators behind establishment and maintenance of pluripotency
Keriayn Smith1, Stephen Dalton
1Paul D Coverdell Center for Biomedical & Health Sciences, Department of Biochemistry & Molecular Biology, University of Georgia, 500 DW Brooks Drive, Athens, GA 30602, USA.
Abstract:
The interplay between transcription factors, epigenetic modifiers, chromatin remodelers and miRNAs form the foundation of a complex regulatory network required for establishment and maintenance of the pluripotent state. Recent work indicates that Myc transcription factors are essential elements of this regulatory system. However, despite numerous studies, aspects of how Myc controls self-renewal and pluripotency remain obscure. This article reviews evidence supporting the placement of Myc as a central regulator of the pluripotent state and discusses possible mechanisms of action.
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