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STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest

Gloria Dimco1, Richard A Knight, David S Latchman

  • 1Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK.

Cell Cycle (Georgetown, Tex.)
|November 19, 2010
PubMed
Summary

Interferon-gamma (IFN-γ) triggers Signal Transducer and Activator of Transcription 1 (STAT1) to regulate cell cycle. STAT1 directly interacts with cyclin D1, promoting its degradation and impacting cell proliferation.

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