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Updated: Jun 6, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
[Progesterone receptor gene polymorphism and recurrent spontaneous abortion]
Evelyn Traina1, Silvia Daher, Camila Sommerauer Franchim
1Departamento de Obstetrícia, Universidade Federal de São Paulo, São Paulo. evelyntraina@hotmail.com
The progesterone receptor gene (PROGINS) polymorphism was not found to be associated with recurrent spontaneous abortion (RSA). This genetic factor does not appear to increase the risk for women experiencing recurrent pregnancy loss.
Area of Science:
- Genetics
- Reproductive Medicine
- Molecular Biology
Context:
- Recurrent spontaneous abortion (RSA) affects a significant number of women, impacting reproductive outcomes.
- The progesterone receptor gene (PROGINS) plays a crucial role in pregnancy maintenance.
- Understanding genetic factors contributing to RSA is vital for developing targeted interventions.
Purpose:
- To investigate the potential association between PROGINS gene polymorphism and the risk of recurrent spontaneous abortion (RSA).
- To compare PROGINS genotype and allele frequencies in women with RSA versus controls.
Summary:
- A case-control study analyzed 85 women with RSA and 157 controls.
- DNA analysis using polymerase chain reaction (PCR) assessed PROGINS polymorphism.
- No significant differences in genotype or allele frequencies were observed between the RSA and control groups.
Impact:
- This study suggests that PROGINS polymorphism is not a significant genetic risk factor for recurrent spontaneous abortion.
- Findings contribute to the understanding of the genetic underpinnings of RSA.
- May guide future research into other genetic markers associated with RSA.
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