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Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Response surface methodology to optimize novel fast disintegrating tablets using β cyclodextrin as diluent.
1Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, Georgia 30341, USA. sameer.g.late@gsk.com
AAPS Pharmscitech
|November 19, 2010
Summary
This study optimized fast disintegrating tablets using β cyclodextrin as a diluent. Results show β cyclodextrin enhances hardness without compromising disintegration, making it ideal for effective oral dosage forms.
Area of Science:
- Pharmaceutical Technology
- Formulation Science
- Drug Delivery Systems
Background:
- Fast disintegrating tablets (FDTs) offer improved patient compliance, especially for pediatric and geriatric populations.
- Optimizing FDTs requires balancing disintegration time and tablet hardness for effective oral administration.
- β cyclodextrin is explored as a novel diluent in FDT formulations.
Purpose of the Study:
- To optimize a novel fast disintegrating tablet formulation using β cyclodextrin as a diluent.
- To investigate the main and interaction effects of formulation parameters on tablet characteristics.
- To apply response surface methodology for efficient formulation optimization.
Main Methods:
- Tablets were formulated using β cyclodextrin (diluent), Croscarmellose sodium (superdisintegrant), and Spray-dried lactose (direct compression aid).
- Direct compression method was employed using a rotary tablet press.
- Tablets were characterized for weight variation, thickness, disintegration time, and hardness.
Main Results:
- Disintegration time was significantly influenced by quadratic terms of β cyclodextrin, Croscarmellose sodium, and Spray-dried lactose.
- Increased β cyclodextrin concentration improved tablet hardness without negatively impacting disintegration time.
- Response surface methodology accurately predicted formulation performance, validating its prognostic ability.
Conclusions:
- β cyclodextrin is a suitable diluent for developing fast disintegrating tablets with adequate hardness.
- The optimized formulation demonstrates the potential of β cyclodextrin in enhancing FDT characteristics.
- Response surface methodology is a valuable tool for optimizing complex pharmaceutical formulations like FDTs.
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