Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Inflammation

Inflammation

Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Causes of Preanalytical Interferences on Laboratory Immunoassays - A Critical Review.

EJIFCC·2020

Same author

Sample management for clinical biochemistry assays: Are serum and plasma interchangeable specimens?

Critical reviews in clinical laboratory sciences·2018

Same author

Robotic assisted radical prostatectomy accelerates postoperative stress recovery: Final results of a contemporary prospective study assessing pathophysiology of cortisol peri-operative kinetics in prostate cancer surgery.

Asian journal of urology·2017

Same author

Preanalytical Nonconformity Management Regarding Primary Tube Mixing in Brazil.

Journal of medical biochemistry·2017

Same author

Patient posture for blood collection by venipuncture: recall for standardization after 28 years.

Revista brasileira de hematologia e hemoterapia·2017

Same author

Lipid profile, changes in laboratory prescriptions are necessary.

Journal of clinical lipidology·2017

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Lipoprotein(a) and ageing.

Giuseppe Lippi¹, Giovanni Targher, Gian Luca Salvagno

¹U.O. Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Italy. glippi@ao.p.it

Clinical Laboratory

|November 20, 2010

Summary

This summary is machine-generated.

Elderly individuals, especially men, show higher lipoprotein(a) (Lp(a)) levels. Elevated Lp(a) may be compatible with longevity, despite being a cardiovascular disease risk factor.

More Related Videos

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Related Experiment Videos

Last Updated: Jun 6, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Area of Science:

Cardiovascular Medicine
Clinical Chemistry
Gerontology

Background:

Lipoprotein(a) (Lp(a)) is a recognized risk factor for cardiovascular disease.
Controversy exists regarding serum Lp(a) levels in the elderly population.

Purpose of the Study:

To investigate and compare serum Lp(a) concentrations in elderly outpatients (>= 75 yrs) versus younger outpatients (< 75 yrs).
To assess the association between age, sex, and Lp(a) levels in a general outpatient cohort.

Main Methods:

Analysis of serum Lp(a) and lipid profiles from 2128 medical outpatients.
Cohort divided into elderly (>= 75 yrs, n=299) and younger (< 75 yrs, n=1829) groups.
Comparison of Lp(a) levels and cardiovascular risk thresholds between age groups and sexes.

Main Results:

Elderly men had a more favorable traditional lipid profile than younger men.
No significant lipid profile differences were observed between elderly and younger women.
Both elderly men and women exhibited significantly higher median Lp(a) concentrations.
The proportion of patients exceeding the 300 mg/L Lp(a) threshold was not significantly higher in the elderly.

Conclusions:

Elderly patients demonstrate similar or higher serum Lp(a) values compared to younger individuals.
Elevated serum Lp(a) concentrations appear compatible with longevity.