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Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

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Early continuous video electroencephalography in neonatal stroke.

Brian H Walsh¹, Evonne Low, Conor O Bogue

¹Neonatal Brain Research Group, Cork University Maternity Hospital, Wilton, Cork, Ireland. Bh.walsh@ucc.ie

Developmental Medicine and Child Neurology

|November 20, 2010

Summary

Early electroencephalography (EEG) detected focal sharp waves in an infant with perinatal stroke before seizures began. These EEG findings evolved with seizure onset, offering potential for earlier diagnosis of neonatal seizures.

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Area of Science:

Neurology
Neonatal Medicine
Neurophysiology

Background:

Perinatal stroke is a significant cause of neonatal seizures and potential long-term neurological deficits.
Current diagnosis of perinatal stroke is often delayed due to subtle clinical signs preceding seizure onset.
Electroencephalography (EEG) is crucial for evaluating neonatal brain activity.

Observation:

A case study of a female infant born at 41 weeks 2 days with a perinatal infarction.
Early EEG (3 hours post-delivery) revealed occasional focal sharp waves in the affected region prior to clinical seizures.
Diffusion-weighted imaging confirmed a left frontal and parietal infarct.

Findings:

Focal sharp waves on EEG increased in frequency, complexity, and amplitude following electroclinical seizures.

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Last Updated: Jun 6, 2026

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

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Published on: June 11, 2020

Preterm EEG: A Multimodal Neurophysiological Protocol

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Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates

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EEG patterns varied with sleep state, with sharp waves more prominent in quiet sleep and often absent in active sleep.

The infant remained seizure-free at 9 months with a normal neurological examination.

Implications:

This case highlights the potential for identifying perinatal stroke via EEG before seizure manifestation.
Understanding the evolution of EEG features in perinatal stroke may lead to earlier diagnosis and intervention.
Early detection can potentially improve long-term neurological outcomes in affected neonates.