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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

Longitudinal and circumferential strain rate, left ventricular remodeling, and prognosis after myocardial infarction

Chung-Lieh Hung1, Anil Verma, Hajime Uno

  • 1Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

Journal of the American College of Cardiology
|November 20, 2010
PubMed

Insights

Strain rate imaging after myocardial infarction (MI) predicts patient outcomes. Both longitudinal and circumferential strain rates are independent predictors of adverse events, with circumferential strain rate also predicting left ventricular remodeling.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Echocardiography

Background:

  • Left ventricular (LV) contractile function post-myocardial infarction (MI) is crucial for long-term prognosis.
  • Tissue deformation imaging, including strain and strain rate, offers a more sensitive assessment of myocardial contractility than traditional systolic function measures.

Purpose of the Study:

  • To evaluate the clinical prognostic significance of longitudinal and circumferential strain (S) and strain rate (SR) in patients following high-risk MI.
  • To determine the association of these deformation parameters with left ventricular (LV) remodeling and clinical outcomes.

Main Methods:

  • The VALIANT Echo study included 603 patients with LV dysfunction or heart failure post-MI.
  • Global longitudinal and circumferential S and SRs were measured using speckle tracking echocardiography.
  • Associations with LV remodeling at 20 months and clinical outcomes were analyzed.

Main Results:

  • Both longitudinal and circumferential SRs independently predicted death or heart failure hospitalization.
  • Circumferential SRs, but not longitudinal SRs, was a strong predictor of LV remodeling.
  • Longitudinal SRs improved the prediction of 18-month survival when added to clinical and standard echocardiographic measures.

Conclusions:

  • Longitudinal and circumferential SRs are independent prognostic markers for outcomes after MI.
  • Circumferential SRs uniquely predicts LV remodeling, suggesting its role in limiting ventricular enlargement post-MI.
Abstract

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