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Updated: Jun 6, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
[Lymphatic system: Anatomy, histology and physiology]
1CHU Saint-Éloi, université de Montpellier I, centre de compétence maladies lymphatiques constitutionnelles, service de médecine vasculaire, 34295 Montpellier cedex 5, France. i-quere@chu-montpellier.fr
Presse Medicale (Paris, France : 1983)
|November 20, 2010
Summary
Lymphoedema research has advanced significantly, moving beyond historical lymphatic system anatomy to incorporate new discoveries in lymphatic endothelial cell markers and genes. This provides a modern understanding of lymphoedema and lymphangiogenesis.
Area of Science:
- Lymphatic system research
- Vascular biology
- Genetics of oedema
Context:
- Historical anatomical descriptions of the lymphatic system remain foundational.
- Recent advances include identifying lymphatic endothelial cell markers.
- Genetic factors in human lymphoedema are increasingly understood.
Purpose:
- To provide an overview of current lymphoedema knowledge.
- To integrate historical anatomical data with recent molecular findings.
- To discuss lymphangiogenesis in the context of lymphoedema.
Summary:
- The understanding of lymphoedema has evolved from early anatomical studies to incorporate modern molecular biology.
- Key developments include the identification of specific lymphatic endothelial cell markers and relevant genes.
- This review synthesizes historical and contemporary knowledge on lymphoedema and lymphangiogenesis.
Impact:
- Advances in understanding lymphoedema pave the way for novel diagnostic and therapeutic strategies.
- Improved knowledge of lymphatic endothelial cells and genes can inform targeted treatments.
- This integrated perspective enhances the fundamental comprehension of lymphatic vascular development and disease.
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