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Updated: Jun 6, 2026

Flow Cytometric Characterization of Murine B Cell Development
Published on: January 22, 2021
Regulation of immunity and autoimmunity by B cells
1Centre for Rheumatology Research, Division of Medicine, University College London, 46 Cleveland Street, London W1T4JF, United Kingdom. c.mauri@ucl.ac.uk
Abstract:
Compelling evidence has demonstrated that IL-10-producing regulatory B cells (B(regs)) are specialized to suppress immune responses and control various immunopathologies. Several reports have provided information on the phenotype, generation, and mechanism of action of B(regs). Recent work has also identified B(regs) in humans and has begun to unravel their phenotype and mode of suppression. A complete analysis of their function in immune-mediated diseases is required for possible future use of B(regs) as a part of new clinical strategies for treating autoimmune diseases and in the induction of transplant tolerance.
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