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Related Experiment Video

Updated: Jun 6, 2026

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

Diffuse large B-cell lymphoma involving the central nervous system.

Gabriela Gualco¹, Lawrence M Weiss, Glen N Barber

¹Consultoria em Patologia, Botucatu, São Paulo, Brazil.

International Journal of Surgical Pathology

|November 20, 2010

Summary

Central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) subtypes impact survival. Non-germinal center DLBCL, common in immunocompromised patients, is linked to worse outcomes.

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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

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Published on: May 19, 2020

Area of Science:

Neurology
Oncology
Immunology

Background:

Central nervous system (CNS) lymphomas, predominantly diffuse large B-cell lymphoma (DLBCL), are increasingly diagnosed in both immunocompetent and immunosuppressed individuals.
Understanding the distinct characteristics of DLBCL across different clinical settings is crucial for accurate diagnosis and treatment.

Purpose of the Study:

To compare the immunophenotype, clinicopathological features, and Epstein-Barr virus (EBV) association of CNS DLBCL in primary immunocompetent cases, primary immunosuppressed cases, and secondary CNS involvement.
To evaluate survival differences based on immunophenotype in primary CNS lymphomas.

Main Methods:

Review of 36 cases of CNS DLBCL, categorized into primary immunocompetent (25 cases), primary immunosuppressed (5 cases), and secondary involvement (6 cases).
Immunophenotyping was performed to classify DLBCL into germinal-center B-cell-like (GCB) and non-germinal B-cell-like (non-GCB) subtypes.
Epstein-Barr virus (EBV) association was assessed.

Main Results:

Only 2 of 36 cases were EBV-positive, both occurring in immunosuppressed patients.
The non-GCB subtype predominated across all groups: 68% in primary immunocompetent, 80% in secondary involvement, and 83% in immunosuppressed cases.
Patients with non-GCB immunophenotype exhibited significantly worse survival compared to those with GCB subtype CNS lymphomas.

Conclusions:

The non-GCB immunophenotype is the predominant subtype of CNS DLBCL across various clinical settings and is associated with poorer survival.
EBV positivity is rare in CNS DLBCL, primarily observed in immunosuppressed individuals.
Further research into targeted therapies for non-GCB CNS DLBCL is warranted.