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Updated: Jun 6, 2026

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

Brown adipose tissue and aging.

Virgile Lecoultre1, Eric Ravussin

  • 1Human Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.

Current Opinion in Clinical Nutrition and Metabolic Care
|November 20, 2010
PubMed
Summary
This summary is machine-generated.

Brown adipose tissue (BAT) activity persists throughout life, declining with age. Activating BAT offers a potential therapeutic strategy for metabolic diseases and weight management.

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Area of Science:

  • Metabolic physiology
  • Adipose tissue biology
  • Aging research

Background:

  • Brown adipose tissue (BAT) was historically considered a neonatal tissue for thermogenesis, disappearing after birth.
  • Recent functional imaging studies reveal persistent BAT activity throughout adulthood.
  • Age-related decline in BAT function is a growing area of research.

Purpose of the Study:

  • To review the impact of aging on brown adipose tissue (BAT) function.
  • To explore BAT as a potential therapeutic target for age-related metabolic diseases.
  • To discuss advancements in imaging techniques for BAT assessment.

Main Methods:

  • Review of recent scientific literature on BAT function and aging.
  • Analysis of functional imaging techniques (e.g., PET/CT) for BAT detection.
  • Discussion of factors influencing BAT activity, including age, sex, and weight.

Main Results:

  • Functional imaging methods like PET/CT may underestimate active BAT prevalence.
  • Factors contributing to age-related BAT decline are unknown but linked to the sympathetic nervous system and thyroid axis.
  • BAT activity is reduced in males and overweight individuals; however, BAT can be recruited throughout life.

Conclusions:

  • Advanced imaging techniques offer improved estimation of adult BAT mass.
  • The high metabolic rate of BAT suggests its potential for activation.
  • Targeting BAT mass and activity presents a promising strategy for body weight management.