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Hair Cells01:22

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.

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Related Experiment Video

Updated: Jun 6, 2026

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea
12:02

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea

Published on: January 1, 2016

Expression of peripherin in human cochlea.

Wei Liu1, Anders Kinnefors, Marja Boström

  • 1Department of Otolaryngology, Uppsala University Hospital, 75185 Uppsala, Sweden. lwoo24@gmail.com

Cell and Tissue Research
|November 20, 2010
PubMed
Summary

Peripherin (PP) is a protein found in the human cochlea. This study shows PP is a specific marker for outer hair cell (OHC) innervation, aiding in understanding auditory system connections.

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Related Experiment Videos

Last Updated: Jun 6, 2026

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea
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Area of Science:

  • Neuroscience
  • Otolaryngology
  • Cell Biology

Background:

  • The organ of Corti has inner (IHCs) and outer hair cells (OHCs).
  • These cells have distinct innervation patterns: IHCs by type I neurons and OHCs by type II neurons.
  • Efferent systems also innervate these structures.

Purpose of the Study:

  • To analyze the expression of peripherin (PP) in the human cochlea.
  • To determine if PP can serve as a marker for OHC innervation.

Main Methods:

  • Immunohistochemical analysis of human cochlear tissue.
  • Investigating the expression patterns of peripherin (PP).

Main Results:

  • Peripherin (PP) is specifically expressed in the afferent neurons innervating outer hair cells (OHCs).
  • Type II spiral ganglion neurons, which innervate OHCs, intensely express PP.
  • PP expression is localized to the OHC system's innervation.

Conclusions:

  • Peripherin (PP) is a reliable marker for identifying the innervation of the outer hair cell (OHC) system in humans.
  • This finding aids in characterizing the complex neural connections within the human cochlea.