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Updated: Jun 6, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
[Clinical characteristics, progression and risk factors of geographic atrophy]
C K Brinkmann1, C Adrion, U Mansmann
1Universitäts-Augenklinik Bonn, Ernst-Abbe-Strasse 2, Bonn, Deutschland. christian.brinkmann@ukb.uni-bonn.de
Abstract:
Geographic atrophy (GA) as the late stage manifestation of age-related macular degeneration (AMD) is a progressive disease process afflicting the retinal pigment epithelium, choriocapillaris and the outer neurosensory retina. GA represents a complex, multifactorial disease governed by the interdependence of genetic, endogenous and exogenous factors. Diagnosis and monitoring of GA progression is largely based on various retinal imaging modalities. After the breakthrough in the treatment of wet AMD GA represents a large clinical challenge. Recent studies have contributed to a better understanding of the pathophysiological pathways, natural history and predictive markers for progression.
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