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Asymmetrical Flow Field-Flow Fractionation for Sizing of Gold Nanoparticles in Suspension
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Field-flow fractionation: addressing the nano challenge.

S Kim Ratanathanawongs Williams1, J Ray Runyon, Akram A Ashames

  • 1Department of Chemistry and Geochemistry, Colorado School of Mines, Golden, CO 80401, USA. krwillia@mines.edu

Analytical Chemistry
|November 25, 2010
PubMed
Summary

Field-flow fractionation (FFF) is an advanced analytical technique for separating and characterizing nanoscale materials. Its versatility addresses challenges in analyzing small sample components across diverse scientific fields.

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biology

Background:

  • Field-flow fractionation (FFF) is emerging as a powerful suite of analytical methods.
  • These techniques are crucial for separating and characterizing complex samples.
  • Analyzing nanometer-sized components presents significant scientific challenges.

Purpose of the Study:

  • To discuss the capabilities and versatility of FFF techniques.
  • To highlight the challenges in analyzing nanometer-sized sample components.
  • To showcase insights gained from FFF applications.

Main Methods:

  • Field-flow fractionation (FFF) encompasses various separation techniques.
  • These methods utilize external fields to fractionate sample components.

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  • Characterization is performed based on differing responses to the applied field.

    • Main Results:

    • FFF techniques demonstrate significant versatility in separating diverse macromolecules, nanoparticles, and particulates.
    • The methods provide valuable insights into the analysis of complex nanoscale systems.
    • Applications span materials science, biology, and other scientific disciplines.

    Conclusions:

    • Field-flow fractionation (FFF) is a maturing analytical technology.
    • Its capabilities are essential for overcoming challenges in nanoscale analysis.
    • FFF offers broad applicability and valuable insights across scientific research.