Related Experiment Video
Updated: Jun 6, 2026
Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
Published on: January 4, 2019
Effects of platelet-rich plasma on sinus bone graft: meta-analysis
Ji-Hyun Bae1, Young-Kyun Kim, Seung-Kwon Myung
1Department of Conservative Dentistry, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.
Background:
This meta-analysis investigates the effects of platelet-rich plasma (PRP) on the sinus bone graft.
Methods:
PubMed, the Cochrane Library, and EMBASE were searched in January 2010.
Results:
Of 61 articles searched, eight controlled clinical trials, which included a total of 352 sinus bone graft cases in 191 patients, were included in the final analysis. In the fixed-effects meta-analysis, the implant survival was not significantly different between two groups in the patient-based data of four studies (relative risk [RR]: 1.02; 95% confidence interval [CI]: 0.97 to 1.08) and in the implant-based data of three studies (RR: 1.02; 95% CI: 0.99 to 1.04). The bone formation was significantly greater in the intervention group in the random-effects model (standardized mean difference [SMD]: 1.30; 95% CI: 0.21 to 2.39) in five studies with significant heterogeneity (I(2) = 76.2%). The bone-to-implant contact was not significantly different between two groups in the random-effects model (SMD: 1.02; 95% CI: -1.65 to 3.70) in two studies with significant heterogeneity (I(2) = 82.4%).
Conclusion:
The present study indicates that there was sufficient evidence to support the use of PRP for bone formation on a sinus bone graft, whereas there was no significant effect on the implant survival and bone-to-implant contact.
