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Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jun 6, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Pharmacotherapies for glaucoma.

¹Department of Ophthalmology, 4013 Durham Research Center, 985840 Nebraska Medical Center, Omaha, NE 68198-5840, USA. ctoris@unmc.edu

Current Molecular Medicine

|November 25, 2010

Summary

Glaucoma treatment focuses on lowering intraocular pressure (IOP) through medications that reduce aqueous humor production or enhance its outflow. This review covers current and emerging pharmacological strategies for managing glaucoma effectively.

Area of Science:

Ophthalmology
Pharmacology

Background:

Glaucoma involves progressive optic nerve damage and vision loss.
Lowering intraocular pressure (IOP) is the primary treatment goal.

Purpose of the Study:

To review current pharmacological treatments for glaucoma.
To discuss emerging drugs for future glaucoma management.

Main Methods:

Classification of IOP-lowering drugs based on mechanism (inflow vs. outflow).
Summary of drugs targeting aqueous humor dynamics.
Inclusion of established and novel therapeutic agents.

Main Results:

Inflow drugs (e.g., beta-blockers, carbonic anhydrase inhibitors) decrease aqueous humor production.

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Last Updated: Jun 6, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

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Outflow drugs (e.g., prostaglandin analogs, cholinergics) enhance drainage.

Some medications offer combined inflow/outflow effects.

Conclusions:

Pharmacological interventions are crucial for glaucoma management.
Understanding drug mechanisms aids in selecting effective treatments.
Ongoing research promises new therapeutic options for glaucoma.