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Updated: Jan 24, 2026

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

Cutaneous endometriosis.

J M Fernández Vozmediano¹, J C Armario Hita, J Cuevas Santos

¹Dermatology Department, University Hospital of Puerto Real, University of Cadiz, Spain. fdezvozmediano@dermasur.com

International Journal of Dermatology

|November 25, 2010

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A rare case of endometriosis presenting as a scar tumor after cesarean delivery was observed. This ectopic endometrial tissue in the skin exhibited cyclical changes mirroring the menstrual cycle.

Area of Science:

Dermatology
Gynecology
Pathology

Background:

Endometriosis is a condition where endometrial-like tissue grows outside the uterus.
Cutaneous endometriosis is a rare manifestation, often associated with surgical scars like cesarean sections.

Observation:

A 32-year-old patient developed an asymptomatic tumor at a prior cesarean scar.
The tumor showed cyclical variations in size, color, and consistency with the menstrual cycle.
No history of bleeding from the tumor was reported.

Findings:

Dermatopathologic examination confirmed ectopic endometrial glandular tissue within the reticular dermis.
The entire thickness of the dermis was involved by the endometrial tissue.
This confirms a diagnosis of cutaneous endometriosis at the cesarean scar site.

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Last Updated: Jan 24, 2026

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

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Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis

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Implications:

This case highlights the importance of considering endometriosis in scar-related tumors, especially with cyclical symptoms.
Accurate diagnosis through dermatopathology is crucial for appropriate management.
Understanding the behavior of ectopic endometrial tissue in the skin can inform future treatment strategies.